Indian Journal of Advances in Chemical Science Volume: 5, Issue: 1, January 2016


ISSN No.: 2320-0898 (Print); 2320-0928 (Electronic)

DOI: 10.22607/IJACS.2017.501005  



Research Article


      Design, Synthesis, Characterization and Biological Activity of Novel Thieno[2,3-d]pyrimidine Derivatives    
Virupakshi Prabhakar*, Kondra Sudhakar Babu, L. K. Ravindranath, J. Latha
A new series of N-(4-(substituted amino) thieno[2,3-d]pyrimidin-2-yl) thiophene/Furan-2-carboxamide (7 a-j) derivatives were synthesized by a five-step procedure that afforded advantages of mild reaction conditions, simple protocol and good yields. Several thieno[2,3-d]pyrimidines have been prepared from methyl 2-aminothiophene-3-carboxylate (1). The structures of the final compounds were confirmed by infrared, nuclear magnetic resonance, and electron impact mass spectrum. The final compounds were screened for their antibacterial activity against Staphylococcus aureus and Bacillus subtilis from Gram-positive group of bacteria. Pseudomonas aeruginosa and Escherichia coli from Gram-negative group of bacteria. Antifungal activity against Aspergillus niger and Candida albicans. Antibacterial and antifungal activities were evaluated and compared with the standard drugs such as amoxicillin and fluconazole. From antibacterial and antifungal activity screening results, it has been observed that compounds 8j, 8i, 8h and 8g possess good activity.

Key words:  Thieno[2,3-d]pyrimidine, Acid-amine coupling reaction, 2, 4-di chloro thieno[2,3-d]pyrimidine, Anti-bacterial, Anti-fungal activity, Amoxicillin, Fluconazole.



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