Indian Journal of Advances in Chemical Science Volume: 5, Issue: 1, January 2016

 
             
   
   

ISSN No.: 2320-0898 (Print); 2320-0928 (Electronic)

DOI: 10.22607/IJACS.2017.501006

 

   

Research Article

 

      Synthesis, Antimicrobial, and Antioxidant Activities of Some Novel Flavones and Pyrazolines Derived from Chalcones    
Naqui Jahan Siddiqui* Chaitali Wasake, Mohammad Idrees
ABSTRACT
 
In this work, synthesis of four novel flavones (2a-d) and four pyrazoline derivatives (3a-d) have been described. 2-hydroxy chalcones (1a-d) underwent oxidative cyclization with I2-dimethyl sulfoxide to afford 2a-d, whereas condensation cyclization of the same chalcones with hydrazine hydrate in ethanol yielded 3a-d. Chalcones required were synthesized by Claisen-Schmidt condensation of substituted 2- hydroxy acetophenones (a-d) and benzyloxy benzaldehyde (1). The structures of the title compounds 2a and 3a were characterized by chemical reactions, elemental analysis, and spectral methods such as IR, 1H NMR and mass spectra. The synthesized compounds were evaluated for in-vitro antibacterial and antioxidant activities against standard. The zone of inhibition for some of the newly synthesized compounds showed notable antibacterial activity against selected bacterial strains compared with chloramphenicol. Significant antioxidant activities were also shown by flavones and pyrazolines.
     
     

Key words:  Flavones, Pyrazolines, Benzyloxy benzaldehyde, Chalcones, Antibacterial antioxidant.

 

 

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