Indian Journal of Advances in Chemical Science Volume: 5, Issue: 2, April 207


ISSN No.: 2320-0898 (Print); 2320-0928 (Electronic)

DOI:  10.22607/IJACS.2017.502006



Research Article


      Investigation on Citric Acid-based Nano Hydroxyapatite Composite for Dental Bone Graft    
Chaurasia Priya Dayashankar, B. S. Madhukar, A. P. Gnana Prakash, P. C. Deepika*, Siddaramaiah
Citrate is a well-known kreb cycle product, makes up around 90% of the total content is located in the skeletal system. Hydroxyapatite (HA) is the most widely accepted biomaterial for the repair and reconstruction of bone tissue defects. It is biocompatible, bioactive, osteoconductive, non-toxic, non-inflammatory, and non-immunogenic. Periodontal regeneration is defined as the restoration of lost periodontium or supporting tissues and includes the formation of new alveolar bone, new cementum, and periodontal ligament. Initially, the majority of synthetic materials were based on calcium phosphates, such as HA and beta-tricalcium phosphate, because of their ability to replicate the native mineral constituent of bone tissue. Although biomimetic and osteogenic, their applications are severely limited when fabricated into porous structures due to the inherent brittleness and very slow degradation rates. To improve their utility, the hybridization of bioceramics and biodegradable polymers has been widely adopted to reform the mechanical properties and bioactivity of the resulting materials. Thus, a scaffold was prepared, that is HA was incorporated in the elastomeric polymer (poly-1,8-octanediol), which contains citric acid as the additive factor, to enhance the formation of bone and bone mineral density. This study aims to evaluate citric acid-based nano HA composite graft in the regeneration of supporting bone around the teeth over 1 year.

Key words: Periodontitis, Bone regeneration, Citric acid.



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