Indian Journal of Advances in Chemical Science Volume: 5, Issue 4: , September 2017

 
             
   
   

ISSN No.: 2320-0898 (Print); 2320-0928 (Electronic)

DOI:  10.22607/IJACS.2017.504007

 

   

Research Article

 

      Synthesis of (4-Bromo-3-Fluorophenyl)(Pyrimidin-5-yl)Methanol and their
Transition Metal Complexes, Spectral, X-ray Powder Diffraction, Cytotoxicity,
Molecular Docking, and Biological Evaluation
   
R. Mohammed Shafeeulla, Ganganaik Krishnamurthy*, Halehatti S. Bhojynaik,
T. Manjuraj1, Subba Poojari
ABSTRACT
 

The article deals with a study of a new series of transition metal complexes such as Co(II), Ni(II), Cu(II), and Zn(II) with pyrimidine-based ligand (4-bromo-3-fluorophenyl)(pyrimidin-5-yl)methanol; the novel ligand has been synthesized through Barbier-type reaction and structurally characterized by 1H nuclear magnetic resonance, infrared, ultraviolet-visible, and powder X-ray powder diffraction (XRD) spectral techniques. The powder XRD studies reveal that all complexes are in crystalline nature. The cytotoxic activity of the complexes and the uncoordinated ligand against human breast cancer (MCF-7) and chronic myelogenous leukemia cell line (K-562) exhibits good viability in the range of 52.11-66.23% at the concentration >100-110 μg/mL as compared to the inhibition in the untreated cells. The result of antibacterial activity revealed that the complexes of cobaltand copper are active against the studied bacteria and fungi, and the cytotoxicity studies are correlated with the computational docking analysis.
 

     
     

Key words:  Barbier reaction, Lithium metal, Sonochemistry.

 

 

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