Indian Journal of Advances in Chemical Science Volume: 5, Issue 4: , September 2017

 
             
   
   

ISSN No.: 2320-0898 (Print); 2320-0928 (Electronic)

DOI:  10.22607/IJACS.2017.504017

 

   

Research Article

 

      Levels of Some Trace Elements in Sera of Patients with Lung Cancer and in Smokers    
Falah S. Al-Fartusie*, Aliea Hafudh, Noor Mustafa, Hassanain Al-Bermani, Ali Y. Majid
ABSTRACT
 

Lung cancer is one of the most common leading causes of cancer mortality around the world. Many efforts have been made recently to use element contents in human body to aid for diagnosing various diseases including cancer. Accordingly, this study aimed to investigate the serum contents of elements Cr, Cu, Mn, Ni, Zn, Mg, and Fe of lung cancer patients and compared them with those found in smokers and non-smoking controls using atomic absorption spectrophotometry technique. The results obtained showed that there were significantly lower levels of Zn, Fe, and Mg (p<0.001) in patients and smokers than in non-smokers. The Zn and Mg levels of patients were significantly lower than in smokers. The serum levels of Cu, Mn, Ni, and Cr were significantly higher (p<0.001) in lung cancer patients than in smokers and controls. In addition, it was found out that the Cu/Zn ratio was significantly higher in patients and smokers than those of controls. The results suggest that adequate intake of Zn and Mg may have a protective role in the occurrence of lung cancer, while the high levels of Cu, Mn, Ni, and Cr may cause a threat of lung cancer. It is also possible to conclude that exposure to cigarette smoke leads to impair oxidant defense system. The data suggest that Cu/Zn ratio could be of great value in diagnosis and evaluating the lung cancer. In addition, it is possible to rely on trace elements to give indications to warn, especially the smokers, of the risk of lung cancer.

     
     

Key words:Lung cancer, Trace elements, Cu/Zn ratio, Atomic absorption spectrometry, Smoking.

 

 

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