Indian Journal of Advances in Chemical Science Volume: 6, Issue 1: , January 2018

ISSN No.: 2320-0898 (Print); 2320-0928 (Electronic)

DOI: 10.22607/IJACS.2018.601008

Research Article

In this paper, a sensitive, accurate, and rapid spectrophotometric method has been reported for the determination of labetalol (LBT) in pure and pharmaceutical formulations. The proposed method is based on the formation of charge-transfer complex between the drug and 2, 3-dichloro-5, 6-dicyano-p-benzoquinone. The absorbance of the formed charge-transfer complex was measured at 460 nm. The developed method was evaluated in terms of standard deviation (SD), relative SD, correlation coefficient, limit of detection, and limit of quantitation. Molar absorptivity and Sandell’s sensitivity were calculated at the optimum experimental conditions. The applicability of the proposed method was ascertained by recovery studies which indicated that the present methods can be successfully applied for the determination of LBT in pure and pharmaceutical formulations.

Key words: Spectrophotometric method, Labetalol, 2, 3-Dichloro-5, 6-dicyano-p-benzoquinone, Charge-transfer complex, Molar absorptivity.

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