|
Two copper complexes of type [Cu(phen)(L-Ser)(Tsc)]NO3
(1), [Cu(bpy)(L-Ser)(Tsc)]NO3 (2) (L-ser = L-serine, Tsc =
Thiosemicarbazide, phen = 1,10-phenanthroline, and bpy =
2,2’-bipyridyl) have been synthesized and characterized by elemental
analyses, ultraviolet-visible, infrared, and electron paramagnetic
resonance (EPR) spectral studies. Based on elemental analyses and
EPR studies confirm that two complexes have five coordinated
geometry. DNA-binding properties of these metal complexes were
investigated using absorption spectroscopy, fluorescence
spectroscopy, viscosity measurements, and cyclic voltammetry. The
binding ability of complexes differs in terms of binding constant;
this may be attributed to difference in ligand coordinated the metal
center, complex 1 shows higher binding affinity than complex 2.
Complexes 1 and 2 have good antibacterial and antifungal activity on
comparing with standard drugs. |
