Indian Journal of Advances in Chemical Science Volume: 6, Issue 4: , December 2018

ISSN No.: 2320-0898 (Print); 2320-0928 (Electronic)

DOI: 10.22607/IJACS.2018.604003

Research Article

Amberlite Infrared-120 Catalyzed Synthesis of 6-Aryl-5H-Quinazolino[4,3-b]Quinazolin8(6H)-one Derivatives as Anticancer Agents

Varimadugu Aruna, H. Sudhakar, Gangadhar Thalari*, Naveen Mulakayala

ABSTRACT

Amberlite infrared (IR)-120 catalyzed synthesis of 6-aryl-5H-quinazolino[4,3-b]quinazolin8(6H)-one derivatives was reported. 2-(2-aminophenyl)quinazolin-4(3H)-ones on reaction with aromatic aldehydes using Amberlite IR-120 resin yielded a variety of 6-aryl-5H-quinazolino[4,3-b]quinazolin-8(6H)-one derivatives in good to excellent yields. This method has the advantages of high yields, easy purification and having mild reaction condition. All the synthesized compounds were evaluated for their anti-proliferative properties in vitro against cancer cell lines, and several compounds were found to be active.

Key words: Amberlite IR-120, 2-(2-Aminophenyl)quinazolin-4(3H)-ones, Aromatic aldehydes, Synthesis, High yield.

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