Indian Journal of Advances in Chemical Science Volume: 6, Issue 4: , December 2018

ISSN No.: 2320-0898 (Print); 2320-0928 (Electronic)

DOI: 10.22607/IJACS.2018.604009

Review Article

In Vitro Hormone-Sensitive Lipase Inhibitory And Antioxidant Activities, Phytochemical Screening Of Methanolic Extract, And Its Fractions From Solanum Nigrum

Jeelan Basha Shaik, Ramakrishnan Ranjani, Kandrakonda Yalamanda Rao, Damu Amooru Gangaiah*

ABSTRACT

Solanum nigrum (SN) Linn. (Solanaceae) methanolic extract and its fractions were investigated for their health-benefit properties, in particular with respect to antioxidant activity and inhibitory ability toward key enzyme hormone-sensitive lipase (HSL) with impact in diabetes and obesity. The SN chloroform fraction was the most promising in regard to the antioxidant effects, namely in the scavenging capacity of the free radicals 2,2-diphenyl-1-picrylhydrazyl and 2,2-azinobis[3-ethylbenzthiazoline]-6-sulfonic, as well as the most effective inhibitor of HSL. In addition, the phytochemical screening of the active fraction was also carried out. These results revealed that chloroform fractions of the methanolic extract of SN bears strong HSL inhibitory and antioxidant properties; it can, therefore, be used as a potential antidiabetic herb.

Key words: Hormone sensitive lipase, Solanum nigrum Linn, Type 2 diabetes mellitus.

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