Indian Journal of Advances in Chemical Science Volume: 8, Issue :1 , January 2020

ISSN No.: 2320-0898 (Print); 2320-0928 (Electronic)

DOI: 10.22607/IJACS.2020.801002 

Research Article

Montmorillonite/sodium alginate/poly (vinylpyrrolidone-co-vinyl acetate)/nanocomposite beads as an oral extended drug vehicle: Intercalation and in-vitro release of glycopyrrolate

O. Sreekanth Reddy, M.C.S. Subha*, C. Madhavi, K. Chowdoji Rao, B. Mallikarjuna

ABSTRACT

The aim of the present study was to fabricate nanocomposite clay beads based on sodium alginate/poly (vinylpyrrolidone-co-vinyl acetate)/montmorillonite (MMT) for controlled release of glycopyrrolate (GLY) drug by simple ionotropic gelation technique. The nanocomposite clay beads were obtained. In the present work we examine the beneficial effects of MMT mineral as drug carrier for GLY because clay minerals play a vital role in drug delivery applications. The developed micro beads were characterized by fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), X-ray diffraction (X-RD), energy-dispersive X-ray spectra (EDS) and scanning electron microscopy (SEM). The effect of MMT content on drug intercalation kinetics, drug encapsulation efficiency and the drug release of the nanocomposite beads were investigated. Drug release kinetics of intercalated GLY has been investigated in both simulated intestinal fluid (pH 7.4) and simulated gastric fluid (pH 1.2) at 37oC and also various kinetic models (zero, first, Higuchi and Korsmeyer-Peppas) have been used to find out the drug release profile. The drug release studies suggested that controlled release of GLY from nanocomposite beads have been observed during in-vitro release experiments.

Key words: Sodium alginate, Poly (vinylpyrrolidone-co-vinyl acetate), Montmorillonite, Nanocomposite clay beads, Glycopyrrolate

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