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The metabolic pathways of uric acid
have been studied in biological chemistry (enzymatic reactions).
However, the course of some reported chemical reactions is unknown.
In this communication, we provide the route of two independent
oxidations of uric acid, with different reagents and reaction media.
The electron flow is given, step by step, until the final product:
allantoin. The intermediate reactions are fully commented. |
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Key words: Allantoin,
Epoxidation, Nitrene, Push-pull effects, Ring closure and opening. |
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