Indian Journal of Advances in Chemical Science, Volume: 9, Issue :3, August 2021

ISSN No.: 2320-0898 (Print); 2320-0928 (Electronic)

DOI: 10.22607/IJACS.2021.903005

Research Article

Synthesis, Molecular Docking, Antibacterial, and Antifungal Studies of Co (II)
and Cu (II) Complexes of N¹, N²-Bis((1,3-Diphenyl-1H-pyrazol-4-yl) Methylene)
Ethane-1,2-Diamine

ABSTRACT

1,3-Diphenyl pyrazole terminated ligand N1,N2-Bis((1,3-diphenyl-1H-pyrazol-4-yl)methylene)ethane-1,2-diamine and its
cobalt and copper complexes were synthesized. The compounds were characterized by elemental analysis, Ultraviolet–visible, Fourier transform infrared 1HNMR, and 13NMR spectroscopic techniques. The spectroscopic data support the structure of the compounds. The in vitro antimicrobial activities against some bacterial and some fungal strains of the synthesized compounds were analyzed and compared with the standard drugs. The result showed that the metal complexes are good candidates as antimicrobial agents than the ligand at the same concentration. The molecular docking studies were carried out using the online software Arguslab 4.0.1 and revealed that both the ligand and its complexes exhibiting a possible interaction with the proteins fibroblast growth factor receptors, c-Met, and vascular endothelial growth factor.

Key words:  1,3-Diphenyl pyrazole derivatives, Metal complexes, Antibacterial study, Antifungal activity, Molecular docking studies

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