Dr. Prolay Das
Dr. Prolay Das
Associate Professor
Ph.D, Georgia Institute of Technology, Atlanta, USA
Ph: +91-612-302 8057
Research Areas : DNA self assembly for production of 3-dimensional functional Nanostructures.
Clustered DNA damage and DNA repair mechanism in Nucleosome core particles.
Research Group
bhavini kumari
Expertise: Clustered DNA damage and repair
Email: bhavini [*AT] iitp.ac.in
seema Singh
Expertise: Nanoparticle-DNA system for biomed applications
Email: seema294singh [*AT] iitp.ac.in
Expertise: DNA based biosensing of toxins
Email: sonam.pch16 [*AT]iitp.ac.in
Former Group Members
vandana singh
Vandana Singh
PhD, 2015
rina kumari
PhD, 2016
Anirban Chakraborty
M. Tech., NanoSc. & Tech 2014
Sumit K. Singh
M. Tech., NanoSc. & Tech 2015
Professional Experience :
  • Postdoctoral Research Associate, Brookhaven National Laboratory, New York, USA, 2008-2009.
  • HOD (Senior Lecturer), Dept. of Biotechnology & Environmental Science, EIILM University, Sikkim, 2009- 2010.
Teaching :
  • CH305 (Biochemistry and Biotechnology) for B. Tech CST
  • CH304 (Petroleum and Petrochemistry) for B. Tech CST
  • CH429 (Biochemistry) for M. Sc. 1st year
  • CH501:(Nanobiotechnology) for M. Tech, NanoSc. & Tech
  • CH512:(Nanotechnology for medical Diagnostics and Therapy) for M. Tech, NanoSc. & Tech.
  • NT513: (Nanomaterial synthesis Lab (Chemistry part)) for M. Tech, NanoSc. & Tech.
  • CH705:(Bioanalytical Techniques) for PhD
Publications :
  • Biosensing of solitary and clustered abasic site DNA damage lesions with copper nanoclusters and carbon dots, Seema Singh, Manoj K. Singh and Prolay Das, Sensors and Actuators B: Chemical, 2017, doi.10.1016/j.snb.2017.08.100.
  • Self-assembly of DNA-porphyrin hybrid molecules for the creation of antimicrobial nanonetwork, Rina Kumari, Mohd. Imran Khan, Sourav Bhowmick, Kislay K. Sinha, Neeladri Das and Prolay Das, Journal of Photochemistry and Photobiology B: Biology, Volume 172, July 2017, Pages 28–35.
  • Carbon dot - Unique reinforcing filler for polymer with special reference to physico-mechanical properties, P.R. Sreenath, Seema Singh, M.S. Satyanarayana, Prolay Das, K. Dinesh Kumar, Polymer, 2017, 112, 189-200.
  • Carbon dots assisted formation of DNA hydrogel for sustained release of drug, Seema Singh, Anshul Mishra, Rina Kumari, Kislay K. Sinha, Manoj K. Singh and Prolay Das, Carbon, 2017, 114, 169-176.
  • A quantum dot–MUC1 aptamer conjugate for targeted delivery of protoporphyrin IX and specific photokilling of cancer cells through ROS generation, Seema Singh,  Pravin Jha, Vandana Singh, Kislay Sinha, Sahid Hussain,  Manoj K. Singh and  Prolay Das, Integrative Biology, 2016,8, 1040-1048.
  • Impeded repair of abasic site damaged lesions in DNA adsorbed over functionalized multiwalled carbon nanotube and graphene oxide, Rina Kumari, Titash Mondal, Anil K. Bhowmick and Prolay Das, Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 2016, accepted.
  • Hierarchical coassembly of DNA–triptycene hybrid molecular building blocks and zinc protoporphyrin IX, Rina Kumari, Sumit Singh, Mohan Monisha, Sourav Bhowmick, Anindya Roy, Neeladri Das and Prolay Das, Beilstein Journal of Nanotechnology, 2016, 7, 697–707.
  • Accelerated processing of solitary and clustered abasic site DNA damage lesions by APE1 in the presence of aqueous extract of Ganoderma lucidum, Bhavini Kumari, Prolay Das and Rekha Kumari, Journal of Biosciences, 2016, DOI 10.1007/s12038-016-9614.
  • A family of mixed-ligand oxidovanadium(V) complexes with aroylhydrazone ligands: a combined experimental and computational study on the electronic effects of para substituents of hydrazone ligands on the electronic properties, DNA binding and nuclease activities, Debashis Patra, Nirmalendu Biswas, Bhavini Kumari, Prolay Das, Nayim Sepay, Shamba Chatterjee, Michael G. B. Drewe and Tapas Ghosh, RSC Advances, 2015,5, 92456-92472
  • Self assembled nanocages from DNA–protoporphyrin hybrid molecules, Vandana Singh, Mohan Monisha, Roy Anindya and Prolay Das, RSC Advances, 2015, 5, 89025-89029.
  • Melamine-DNA Encoded Periodicity of Quantum dot Arrays, Seema Singh, Rina Kumari, Anirban Chakraborty, Sahid Hussain, Manoj K., Singh and Prolay Das, Journal of Colloid and Inerface Science, 2015, doi.10.1016/j.jcis.2015.08.064
  • DNA–melamine hybrid molecules: from self-assembly to nanostructures, Rina Kumari, Shib Shankar Banerjee, Anil K. Bhowmick and Prolay Das,Beilstein J. Nanotechnol. 2015, 6, 1432-1438
  • Repair efficiency of clustered abasic sites by APE1 in nucleosome core particles is sequence and position dependent, Vandana Singh, Bhavini Kumari and Prolay Das, RSC Advances, 2015, 5, 23691-23698.
  • DNA mediated assembly of quantum dot–protoporphyrin IX FRET probes and the effect of FRET efficiency on ROS generation, Seema Singh, Anirban Chakraborty, Vandana Singh, Aniruddha Molla, Sahid Hussain, Manoj K. Singh and Prolay Das, Physical Chemistry Chemical Physics (PCCP), 2015, 17, 5973-5981.
  • Synthesis and Characterization of Biocompatible Monotyrosine-Based Polymer and its Interaction with DNA. Radhika Mehta, Rina Kumari, Prolay Das and Anil Kumar Bhowmick, Journal of Material Chemistry B, 2014, 2, 6236-6248.
  • Binding and Interaction of Di- and Tri-Substituted Organometallic Triptycene Palladium Complexes with DNA. Rina Kumari, Sourav Bhowmick, Neeladri Das and Prolay Das, Journal of Biological Inorganic Chemistry, 2014, 19, 1221-1232.
  • Direct Observation of Preferential Processing of Clustered Abasic DNA Damages with APE1 in TATA Box and CpG Island by Reaction Kinetics and Fluorescence Dynamics, Vandana Singh, Bhavini Kumari, Banibrata Maity, Debabrata Seth and Prolay Das, Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2014,766-767, 56-65.
  • Synthesis, characterization and DNA interaction studies of new triptycene derivatives, Sourav Chakraborty, Snehasish Mondal, Rina Kumari, Sourav Bhowmick, Prolay Das, and Neeladri Das, Beilstein Journal of Organic Chemistry, 2014, 10, 1290–1298.
  • Processing of abasic site damaged lesions by APE1 enzyme on DNA adsorbed over normal and organomodified clay, Bhavini Kumari, Shib Shankar Banerjee, Vandana Singh, Prolay Das and Anil K. Bhowmick, Chemosphere, 2014, 112, 503-510.
  • Condensation of DNA—A putative obstruction for repair process in abasic clustered DNA damage, Vandana Singh and Prolay Das, DNA Repair, 2013, 12, 450-457.
  • PEG-mediated one-pot multicomponent reactions for the efficient synthesis of functionalized dihydropyridines and their functional group dependent DNA cleavage activity, Suman Pal, Vandana Singh, Prolay Das and Lokman H. Choudhury, Bioorganic Chemistry, 2013, 48, 8-15.
  • Processing of abasic DNA clusters in hApeI-silenced primary fibroblasts exposed to low doses of X-irradiation; Prolay Das, Paula V. Bennet and Betsy M. Sutherland, Journal of Bioscience, 2011, 36, 105-116.
  • One-Electron Oxidation of Condensed DNA Toroids: Injection-Site dependent Charge (Radical Cation) Mobility; Prolay Das and Gary B. Schuster, Bioconjugate Chemistry, 2008, 19, 1235-1240.
  • Effect of Condensate formation on long-distance radical cation migration in DNA; Prolay Das and Gary B. Schuster; Proceedings of the National Academy of Science, USA, 2005, 102, 14227-14231.
Ongoing Project :
  • DNA guided assembly of Quantum dot-Photosensitizer conjugate for photodynamic therapy Sponsoring Agency: BRNS, Department of Atomic Energy.
Completed projects :
  • Study of Clustered DNA-Damage Repair Mechanism in Nucleosome Core Particles.
    Sponsoring Agency: Department of Science and Technology, Govt. of India.
  • DNA supramolecular self assembly for construction of functional nanostructures
    Sponsoring Agency: Department of Biotechnology, Govt. of India
Conferences :
  • DNA-Organic hybrid molecules-from self-assembly to nanostructures, International Symposium on Nature Inspired Initiatives, March 3-6, 2014, IICT Hyderabad, India.
  • Preferential repair of clustered abasic sites in TATA Box consensus sequence as compared to CpG island, 16th CRSI, National Symposium in Chemistry, IIT Bombay, India.
  • DNA-Melamine Hybrid molecules:  From Self-Assembly to Nanostructures, Recent developments in chemical science & technology, March 15-16, 2014, NIT Rourkela, India
  • Long Distance Radical Cation Migration in DNA Condensates, American Chemical Society Meeting & Exposition, March 26 - 30, 2006, Atlanta, USA
  • Lethargic Repair Process in DNA Condensates with Abasic Clustered Damage, 2013 Bangkok International Conference on Biological Engineering & Natural Science (BBENS), January 25-27, 2013, Bangkok, Thailand
Invited lectures :
  • January 2012: “A Journey to the Old Age- Why do we grow old?” National conference, Mahavir Cancer Hospital, Patna, India.
  • August 2012: “The Wonderful World of DNA”, Dept. of Science & Technology, Govt. of India, Inspire Program, Patna University.
  • March 2013: “The Wonders of Nanotechnology”, Dept. of Science & Technology, Govt. of India, Inspire Program, Patna University.
  • May 2013: “Nanostructures and Nanoconstructions based on DNA”, Birla Institute of Technology, Patna, India.
  • October 2016: “Fluorescence Spectroscopy to Intercept Abasic Site DNA Damage and Repair Mechanism”, TEQIP II sponsored workshop on Fundamentals and Application in Biomolecular Spectroscopy, NIT Patna, Patna, India.

Processing of abasic site damaged lesions by APE1 enzyme on DNA adsorbed over normal and organomodified clay, Bhavini Kumari, Shib Shankar Banerjee, Vandana Singh, Prolay Das and Anil K. Bhowmick, Chemosphere, 2014, 112, 503-510