Indian Journal of Advances in Chemical Science, Volume: 10, Issue : 1, January 2022

ISSN No.: 2320-0898 (Print); 2320-0928 (Electronic)

DOI: 10.22607/IJACS.2022.1001004

Article

Synthesis of Substituted-(3-phenyl-1,2,4-oxadiazol-5yl)-methyl-9-chloro-2,3-
dimethyl-6,7-dihydro-5H-benzocyclohepten-8-carboxylates

P. M. Gomedhika, N. J. P. Subhashini*

ABSTRACT

A novel series of substituted-(3-phenyl-1,2,4-oxadiazol-5-yl)-methyl-9-chloro-2,3-dimethyl-6,7-dihydro-5H-benzocyclohepen-8-carboxylates (5a-h) have been synthesised in satisfactory yields in presence of Caesium carbonate and dry N,N-dimethyl formamide by reacting with the 9-chloro-2,3-dimethyl-6,7-dihydro-5H-benzocyclohepten-8-carboxlic acid (3) with various phenyl-1,2,4-oxadiazoles (4a-h) for 8–10 h at room temperature and their structures were confirmed by 1H NMR, 13C NMR, IR and Mass spectral analyses and they were good agreement with proposed structures.

Key words: Caesium carbonate, N’-hydroxybenzamidines, Phenyl-1,2,4-oxadiazoles, Vilsmeier-Haack-Arnold reaction.

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