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Indian Journal of Advances in Chemical Science, Volume: 10,
Issue : 1, January 2022 |
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ISSN No.: 2320-0898 (Print);
2320-0928 (Electronic)
DOI:
10.22607/IJACS.2022.1001006 |
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Article
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Biological
Significance of some Inclusion Complexes of 4-Thiazolidinone
Derivatives with β-Cyclodextrin |
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Simanchal Dash*
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ABSTRACT |
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A new series of compounds of
(2-Benzothiazolyl-2’)hydrazono-3-phenyl-5-arylidene-4-thiazolidinone
derivatives and
2-phenyl-(3-benzothiazolyl-2’)hydrazono-5-arylidene-4-thiazolidinone
derivative 4(a-i) are prepared from 2-hydrazinobenzothiazole taking
as a starting material. The inclusion complexes of respective
compounds can be prepared with β-cyclodextrins using the
co-precipitation method. These synthesized compounds and their
inclusions have been characterized with their spectral, analytical
data and screened for their antibacterial activities. With the
formation of inclusion complexes, the compounds show more biological
activeness as compared to the parent compounds. Finally, the
antibacterial study proves that the inclusion complexes of 4d show
greater efficiency towards Staphylococcus aureus whereas 4e shows
greater efficiency against Escherichia coli bacteria’s
respectively. |
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Key words: Antibacterial activities, Biological
activeness, Escherichia coli, Inclusion complexes. |
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[Download Full Article
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