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Indian Journal of Advances in Chemical Science, Volume: 10,
Issue : 1, January 2022 |
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ISSN No.: 2320-0898 (Print);
2320-0928 (Electronic)
DOI:
10.22607/IJACS.2022.1001008 |
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Article
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Synthesis,
Spectral Characterization and In vitro Antifungal Activity of New
Naphthyl Thiazolidinones |
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Ajita Yadav, Shafia Mir, Ayaz Mahmood
Dar, Praveen Kumar*
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ABSTRACT |
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Microwave-assisted synthesis of naphthyl
thiazolidinones (4-6) was successfully completed after reacting
naphthyl thiosemicarbazones (1-3) with mercaptoacetic acid (1 mmol)
in the presence of neutral alumina (Al2O3) and a few drops of
piperidine under solvent-free conditions. The characterization of
compounds (4-6) was done by spectral (IR, 1H NMR, 13C NMR and MS)
and analytical data. The new compounds were screened for in vitro
antifungal activity by Disk Diffusion Method during which compounds
depicted moderate to good in vitro antifungal activity. |
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Key words: Antifungal activity, Microwave, Mercaptoacetic
acid, Naphthyl thiazolidinones |
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