Indian Journal of Advances in Chemical Science, Volume: 10, Issue : 4, December 2022

ISSN No.: 2320-0898 (Print); 2320-0928 (Electronic)

DOI: 10.22607/IJACS.2022.1004004

Research Article

Synthesis of Novel Spiro [imidazolidine- pyrazoline]-2, 4-dione Derivatives

Manju Mehta, Bhupinder Mehta*, Seema Gupta, Vijay Kumar Goel

ABSTRACT

The pharmaceutical importance of spiro-imidazolidinedione derivatives is well established. Here, we communicate the synthesis of new spiro [imidazolidine-pyrazoline]- 2,4-diones in two steps. The first step involves the preparation of 5-ary1idene imidazolidine-2,4-dione derivatives by well-known Knoevenagel reaction involving condensation of aromatic aldehydes and imidazolidine-2,4-dione. In the second step, reaction of diazomethane with 5-ary1idene imidazolidine-2, 4-dione resulted in formation of new spiro [imidazolidine-pyrazoline] 2,4-dione derivatives. The synthesized spiro compounds were characterized by spectral analysis. Computational studies have been utilized to explain the stability of tautomeric forms of synthesized compounds. The Swiss ADME studies indicate suitable physiochemical properties, drug-likeliness features, and good oral bioavailability.

Key words: Spiro [imidazolidine-pyrazoline]-2, 4-diones, diazomethane, 5-arylidene imidazolidine-2, 4- diones

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