Indian Journal of Advances in Chemical Science, Volume: 10, Issue : 4, December 2022

ISSN No.: 2320-0898 (Print); 2320-0928 (Electronic)

DOI: 10.22607/IJACS.2022.1004005

Research Article

Synthesis, Characterization, and Antimicrobial Properties of 6-Methoxy-2,3-Dihydro-4H-Chromen-4-One Based Chalcones

Sukanya Pati, Prajna P. Mohanta, Ajaya K. Behera, Hari N. Pati*

ABSTRACT

A new series of α, β-unsaturated ketones were synthesized by the reaction of different aromatic aldehydes with 6-methoxy-2, 3-dihydro-4H-chromen-2-one. The newly synthesized chalcone derivatives 3a–h were characterized by their 1H-NMR, 13C-NMR, IR, and mass spectral data and were further screened for their antibacterial activity. All the synthesized compounds showed good activities in comparison with standard drug nitrofurazone. Among the tested compounds, 3a, 3c, 3e, and 3h showed excellent activity against all four bacterial strains.

Key words: Antimicrobial activity, Chalcones, Claisen-Schmidt reaction, Flavonoids

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