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Indian Journal of Advances in Chemical Science, Volume: 10,
Issue : 4, December 2022 |
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ISSN No.: 2320-0898 (Print);
2320-0928 (Electronic)
DOI: 10.22607/IJACS.2022.1004006 |
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Research Article
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A novel method for
deoxygenation of sugar lactones: a practical route to synthesis of
the key intermediates of the “Statins” |
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Naresh Vempala, A. Jaya Shree*
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ABSTRACT |
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A novel and alternate deoxygenation method for selective removal of
a hydroxyl group in carbohydrates is described. The method could be
used as a synthetic tool to transform complex carbohydrates into
desirable synthetic targets, particularly targets having
1,3-dihydroxy dispositions. The usefulness of this methodology is
demonstrated in the preparation of a (2R, 5S)-dihydroxy hexanoic
acid ester which served as the precursor for generating the side
chain of rosuvastatin calcium, a cholesterol lowering drug. |
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Key words: Carbohydrates, Deoxy sugars, Statins,
Rosuvastatin calcium. |
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[Download Full Article
PDF] |
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