Indian Journal of Advances in Chemical Science,

Volume: 11, Issue : 2, April 2023

ISSN No.: 2320-0898 (Print); 2320-0928 (Electronic)

DOI: 10.22607/IJACS.2023.1102012

Research Article

Synthesis of 1-acetyl- 5-Substitutedaryl-3- [5-(5’-Methoxy-3-Indomethyl)-2-Amino-1, 3, 4-Oxadiazol-2-N-yl] - 2-Pyrazoline Derivatives as Potent Antiinflammatory Agent

ABSTRACT

When 5-(5-methoxy-3-indomethyl)- -1,3,4-oxadiazol- 2-amino substituted chalcones (5a-5e) undergo cyclisation in presence of 99% hydrazine hydrate and few drops of glacial acetic acid and refluxed for 12 h, a novel series of 1-acetyl- 5-substitutedaryl-3- [5-(5’-methoxy-3-indomethyl)-2-amino-1,3,4-oxadiazol-2-N-yl]- 2-pyrazoline can be synthesized. These compounds were characterized by IR, 1HNMR spectroscopy and screened for their promising anti-inflammatory activity.

Key words: : Oxadiazol, Indole, Chalcones, Pyrazoline, anti-inflammatory activity.

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