Synthesis of Diazepine Derivatives and its Potential Antibacterial Characteristics

DOI: 10.22607/IJACS.2023.1104003

Research Article

ABSTRACT

Diazepines are a class of nitrogen-containing heterocycles that have a seven-membered ring structure that includes two atoms of nitrogen. Chalcone-based diazepine moieties have attracted significant interest from researchers due to their increased pharmacological, biological, and therapeutic abilities. The present research included the synthesis of three new diazepine derivatives by the reaction between 1,2-diaminobenzene and three distinct chalcone derivatives. The produced compounds underwent characterization using 1HNMR and Fourier-transform infrared spectroscopies. The diazepines that were obtained were subjected to screening for antibacterial activity against Escherichia coli, Pseudomonas, and Bacillus subtilis. The findings revealed that derivative F exhibited the most potent action against E. coli and B. subtilis, while derivative D showed the greatest activity specifically against B. subtilis.

Key words: Heterocyclic, Diazepine, Antibacterial, Chemistry.

[Download Full Article PDF]

Indian Journal of Advances in Chemical Science,

Volume: 11, Issue : 4, December 2023

ISSN No.: 2320-0898 (Print); 2320-0928 (Electronic)