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It is becoming more and more clear that each cell, even those of the
same type, has a unique identity. This sophistication and the
diversity of cell types in tissue are what are pushing the necessity
for spatially distributed omics at the single-cell (SC) level. SC
chemical assessment, which also provides considerable insight into
biological, clinical, pharmacodynamic, pathological, and toxicity
studies, is crucial to the investigation of cellular omics
(genomics, metabolomics, etc.). Mass spectrometry (MS) as a tool to
image and profile SCs and subcellular organelles facilitates novel
technical expertise for biochemical and biomedical research, such as
assessing the intracellular distribution of drugs and the
biochemical diversity of cellular populations. It has been
illustrated that atmospheric MS (AMS) is a valuable tool for the
rapid, straightforward, and simple analysis of cellular and
subcellular constituents and metabolites in their native state. This
short review examines the advances in AMS on SC analysis that has
been authored in recent years. The discussion also touches on
typical SC AMS assessments and implementations. |
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Key words: Ambient ionization mass spectrometry, Desorption
electrospray, Ambient mass spectrometry, Single-cell mass
spectrometry, Single-cell analysis |
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Indian Journal of Advances in Chemical Science,
Volume: 11, Issue : 4, December 2023
ISSN No.: 2320-0898 (Print);
2320-0928 (Electronic) |
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