Fabrication of Functionally Modified Alginate-based pH-Responsive Hydrogels and their Silver Nanocomposites for Biomedical Applications

DOI: 10.22607/IJACS.2024.1202001

Research  Article

ABSTRACT

Hydrogels have significant economic potential and are attractive prospects for use as biomedical devices, particularly in medication administration and wound healing. In addition, their metal nanocomposites show promise as catalysts in organic transformations. Nevertheless, developing a method to create hydrogels using naturally occurring polysaccharides that have been changed to possess certain functions and can meet the aforementioned criteria is a significant difficulty. The current study focuses on propylene glycol alginate-co-poly (acrylamide). The chemical is a copolymer made up of bis (2-methacryloyloxy) ethyl phosphate and 3-sulfopropyl methacrylate potassium salt. PASB co-polymeric hydrogels were synthesized by a straightforward free radical polymerization process employing potassium persulfate as a crosslinking agent. In addition, we utilized Annona Cherimoya aqueous leaf extract as the reducing agent to create silver nanoparticles (PASB-Ag) using PASB hydrogels as templates in a green method. The PASB and PASB-Ag hydrogels underwent characterization using Fourier transform infrared  spectroscopy, ultraviolet-visible, X-ray diffraction, scanning electron microscopy, and EDAX techniques. The PASB hydrogels effectively contained the anti-cancer medication doxorubicin, resulting in an increase in drug concentration from 40.32 ± 1.3 to
74.02 ± 0.8. In vitro cumulative drug delivery tests were conducted at pH 1.2 and 7.4 and at a temperature of 37°C.

Key words: Hydrogel, Alginate, Drug delivery, Doxorubicin, Anti-cancer.

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Indian Journal of Advances in Chemical Science,

Volume: 12, Issue : 2,  April 2024

ISSN No.: 2320-0898 (Print); 2320-0928 (Electronic)