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Indian Journal of Advances in Chemical Science Volume: 5,
Issue: 1, January 2016 |
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ISSN No.: 2320-0898 (Print);
2320-0928 (Electronic)
DOI:
10.22607/IJACS.2017.501006
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Research Article
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Synthesis, Antimicrobial, and
Antioxidant Activities of Some Novel Flavones and Pyrazolines
Derived from Chalcones |
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Naqui Jahan Siddiqui*
Chaitali Wasake, Mohammad Idrees |
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ABSTRACT |
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In this work, synthesis of four novel
flavones (2a-d) and four pyrazoline derivatives (3a-d) have been
described. 2-hydroxy chalcones (1a-d) underwent oxidative
cyclization with I2-dimethyl sulfoxide to afford 2a-d, whereas
condensation cyclization of the same chalcones with hydrazine
hydrate in ethanol yielded 3a-d. Chalcones required were synthesized
by Claisen-Schmidt condensation of substituted 2- hydroxy
acetophenones (a-d) and benzyloxy benzaldehyde (1). The structures
of the title compounds 2a and 3a were characterized by chemical
reactions, elemental analysis, and spectral methods such as IR, 1H
NMR and mass spectra. The synthesized compounds were evaluated for
in-vitro antibacterial and antioxidant activities against standard.
The zone of inhibition for some of the newly synthesized compounds
showed notable antibacterial activity against selected bacterial
strains compared with chloramphenicol. Significant antioxidant
activities were also shown by flavones and pyrazolines. |
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Key words: Flavones,
Pyrazolines, Benzyloxy benzaldehyde, Chalcones, Antibacterial
antioxidant. |
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[Download Full Article
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KROS Publications |
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