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Indian Journal of Advances in Chemical Science Volume: 6,
Issue 3: , August 2018 |
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ISSN No.: 2320-0898 (Print);
2320-0928 (Electronic)
DOI:
10.22607/IJACS.2018.603009
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Research Article
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Mixed ligand Copper(II) complexes
of polyazole ligands with pendant arms amide and hydrazide – DNA
binding activity |
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Ch. Himasekhar, M. S.
Surendrababu*, P. Gopi Krishna
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ABSTRACT |
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New pyridyl tetrazole ligands
2-(5-(pyridin-2-yl)-1H-tetrazol-1-yl)acetamide (L1),
2-(5-(pyridin-2-yl)-2H-tetrazol-2-yl)acetamide (L2),
2-(5-(pyridin-2-yl)-1H-tetrazol-1-yl)acetohydrazide (L3), and
2-(5-(pyridin-2-yl)-2H-tetrazol-2-yl)acetohydrazide (L4) have been
prepared. These ligands and phenanthroline have been coordinated
with CuCl2.2H2O to furnish corresponding mixed
complexes [Cu(L1)(Phen)]-[Cu(L4)(Phen)]. Electron paramagnetic
resonance spectra of all the copper complexes are characteristic of
square planar geometry, with nuclear hyperfine spin 3/2. DNA binding
studies were carried using UV-Vis absorption spectroscopy. Viscosity
and thermal denature studies revealed that each of these complexes
is avid binders of calf thymus DNA. |
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Key words: Pyridyl-tetrazole,
Pendant arm, Mixed ligand copper complexes, DNA binding properties |
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[Download Full Article
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