Indian Journal of Advances in Chemical Science Volume: 6, Issue 3: , August 2018

ISSN No.: 2320-0898 (Print); 2320-0928 (Electronic)

DOI: 10.22607/IJACS.2018.60301

Research Article

Study to Explore Complexation of Crown Ether with Antidepressant Drug Prevalent in Aqueous System by Physicochemical Contrivance

Ashutosh Dutta, Biraj Kumar Barman, Beauty Mahato, Habibur Rahaman, Mahendra Nath Roy*

ABSTRACT

The inclusion complex of antidepressant drug molecule with crown ether (CE) 15-C-5 was prepared and characterized successfully. The inclusion complexes with CE in the aqueous medium and solid state were studied by different physicochemical methodologies. Formation of inclusion complex was confirmed by 1-H nuclear magnetic resonance and Fourier transform-infrared studies. Surface tension and conductance were studied in the aqueous system; the 1:1 stoichiometric ratio of inclusion complex was obtained. The UV-visible study supported the formation as well as stoichiometry of inclusion. Binding constant and thermodynamic parameters were calculated which supported the high stability and feasibility of the formation of the inclusion complex.

Key words: Crown ether, Inclusion complex, Antidepressant drug, Nortriptyline hydrochloride.

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