Indian Journal of Advances in Chemical Science Volume: 6, Issue 4: , December 2018

ISSN No.: 2320-0898 (Print); 2320-0928 (Electronic)

DOI: 10.22607/IJACS.2018.604004

Research Article

Biological Activity and Variation of Toxicity of Probenecid in Diverse Solvent Systems Probed by Physicochemical Investigation

Niloy Roy, Koyeli Das, Uttara Dey Bhowmick, Soumen Bhattacharjee, Mahendra Nath Roy*

ABSTRACT

Probenecid has an extended and storied history in medicine that has been characterized by unexpected usefulness and a very benign toxicity profile. The solubility of probenecid (PB) in water (H₂O), ethanol (EtOH), ethoxyethanol, ethyl acetate (EtOAc), and ({ethyl acetate (EtOAc) + ethanol (EtOH)}, {ethyl acetate + ethoxy ethanol} binary co-solvent mixtures) was determined at three different temperatures from T = 298.15 K to T = 308.15 K was determined consecutively to open further fields in the clinical treatments.

Key words: Ion-solvent interaction, Cytotoxicity, Probenecid, Ethyl acetate-ethoxy-ethanol, Fluorescence

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