Indian Journal of Advances in Chemical Science Volume: 7, Issue 2: , April 2019

ISSN No.: 2320-0898 (Print); 2320-0928 (Electronic)

DOI: 10.22607/IJACS.2018.702001

Research Article

Host-guest Inclusion Complexation of 3-(2-Napthyl)-D-Alanine with α- and β-Cyclodextrins Explored by Nuclear Magnetic Resonance, Fourier-transform Infrared, High-resolution Mass Spectrometry, Surface Tension, and Conductometric Studies

Binoy Chandra Saha, Subhadeep Saha, Raja Ghosh and Mahendra Nath Roy*

ABSTRACT

Host-guest inclusion complex formation of α-cyclodextrin (α-CYD) and β-CYD with 3-(2-Napthyl)-D-alanine has been investigated. Physicochemical and spectroscopic experimental data offer sufficient evidence about stabilization, carry, and regulatory release of the guest molecule. Surface tension and conductivity studies indicate 1:1 stoichiometry of the inclusion complexes. 1H nuclear magnetic resonance and Fourier-transform infrared studies confirm the inclusion phenomena. The host-guest interactions have been explained on the basis of hydrogen bonding, Van der Waals force, hydrophobic effect, electrostatic force, and exceptional structural effect of host-guest molecules

Key words: Inclusion complex, Cyclodextrin, 3-(2-Napthyl)-D-Alanine, Spectroscopic investigation, Physicochemical studies.

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