Indian Journal of Advances in Chemical Science Volume: 7, Issue :3 , August 2019

ISSN No.: 2320-0898 (Print); 2320-0928 (Electronic)

DOI: 10.22607/IJACS.2018.703005

Research Article

Investigation of Host–Guest InclusDOI 10.22607IJACS.2019.703005.pdfion Complexes of a Neurotransmitter inside into α- and β-Cyclodextrins through Hydrophobic and Hydrophilic Interactions by Physicochemical Approach

Habibur Rahaman, Kalipada Sarkar, Mitali Kundu, Mahendra Nath Roy*

ABSTRACT

In the present work, the formation of inclusion complex of a neurotransmitter, phenylethanolamine with α-cyclodextrin (α-CD) and β-CD (β-CD) was examined from volumetric, viscometric, and spectroscopic studies. The supramolecular interaction between CD and phenylethanolamine has been characterized by volumetric and viscometric and spectral studies. However, the stoichiometry of host–guest of the inclusion complexes was ascertained from Job’s plot calculation from ultraviolet–visible spectroscopy. The association/binding constant of the formation of inclusion complex was calculated from Benesi–Hildebrand equation. The infrared (IR) and 1H-NMR spectroscopy also support the formation of inclusion complexes and the probable manner of inclusion was defined from 1H-NMR and two-dimensional Roesy NMR spectroscopies.

Key words: Phenylethanolamine, Job’s plot, cyclodextrins, Benesi–Hildebrand equation.

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