Indian Journal of Advances in Chemical Science Volume: 7, Issue :4 , December 2019

ISSN No.: 2320-0898 (Print); 2320-0928 (Electronic)

DOI: 10.22607/IJACS.2019.704001

Research Article

Spectrophotometric Method for Estimation of Esomeprazole Magnesium Trihydrate Using Reagents – 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone, Chloranilic Acid, and 1-Chloro-2,4-dinitrobenzene with Charge–Transfer Complex Reaction

N. Subrahmanyeswara Rao, S. Arul Antony*, T. Thirupathi Rao, S. Siva Kumar

ABSTRACT

Three simple, sensitive, and rapid spectrophotometric methods were developed for the estimation of esomeprazole magnesium (ESM) trihydrate in pure and its commercial dosage forms. These methods were based on the formation of charge–transfer reaction between the drug, an n-electron donor and p-acceptors, 2,3-dichloro-5, 6-dicyano-p-benzoquinone, chloranilic acid, and 1-chloro-2,4-dinitrobenzene. The absorbance of the formed charge–transfer complexes was measured and utilized for the determination of ESM in its pure and commercial dosage forms. The developed methods were evaluated in terms of standard deviation, relative standard deviation, correlation coefficient, limit of detection, and limit of quantitation. Molar absorptivity and Sandell’s sensitivity were calculated at the optimum experimental conditions. The validity of the proposed methods was ascertained by recovery studies which indicated that the present methods can be successfully applied for the determination of ESM in pure and commercial dosage forms.
 

Key words: Spectrophotometric methods, Esomeprazole magnesium trihydrate, Charge–transfer reaction, 2,3-dichloro-5,6-dicyano-p-benzoquinone, Chloranilic acid, 1-Chloro-2, 4-dinitrobenzene.

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