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In this manuscript, dual responsive
semi-interpenetrating polymer networks hydrogels (polyvinyl
alcohol/poly(acrylamide-co-(2-dimethylamino)ethyl methacrylate) [PVPAD])
fabricated from (2-dimethylamino)ethyl methacrylate, PVP, and
acrylamide for anti-cancer drug (5-fluorouracil [5-FU]) delivery
application. PVPAD hydrogels are successfully prepared by a simple
free radical polymerization using N,N1-methylene-bis-acrylamide, and
bis[2-methacryloyloxy] ethyl phosphate as a cross-linkers. The
developed hydrogels are characterized by Fourier transform infrared
spectrometer, X-ray diffraction, thermogravimetry, and scanning
electron microscopy analysis to confirm the formation, structural
interactions, thermal, and morphological properties. This study
aimed to investigate the effect of crosslinker on swelling behavior
and delayed release of 5-FU from PVPAD polymeric network. The
studied parameters included: Monomer concentration, crosslinking
agent type and concentration, and their overall effect on swelling
of the hydrogels, drug loading efficiency, diffusion, and in vitro
release characteristics of 5-FU from PVPAD hydrogels.
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Key words: Hydrogel, Poly(vinyl alcohol),
(2-Dimethylamino)ethyl methacrylate, Stimuli responsive, Drug
delivery,
5-Fluorouracil. |
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