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Indian Journal of Advances in Chemical Science, Volume: 9,
Issue : 3, August 2021 |
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ISSN No.: 2320-0898 (Print);
2320-0928 (Electronic)
DOI: 10.22607/IJACS.2021.903018 |
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Research Article
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Microwave-assisted Synthesis of Naphthyl Pyrimidinones and their
Antioxidant Activity |
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Ajita Yadav, Shafia Mir, Praveen Kumar*,
Ayaz Mahmood Dar
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ABSTRACT |
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Microwave-assisted synthesis of naphthyl
pyrimidinones (4-6) was successfully completed after reacting
naphthyl thiosemicarbazones (1-3) with ethyl cyanoacetate in the
presence of neutral alumina (Al2O3) and few drops of piperidine
under solvent-free conditions. The characterization of compounds
(4-6) was done by spectral (IR, 1H-NMR, 13C-NMR, and MS) and
analytical data. The new compounds were screened for antioxidant
activity by DPPH radical scavenging assay, during which compounds
depicted moderate to good DPPH radical scavenging activity. |
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Key words: Antioxidant activity,
Microwave synthesis, Naphthyl pyrimidinones. |
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[Download Full Article
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