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Indian Journal of Advances in Chemical Science, Volume: 9,
Issue : 4, December 2021 |
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ISSN No.: 2320-0898 (Print);
2320-0928 (Electronic)
DOI: 10.22607/IJACS.2021.904004 |
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Review Article |
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Thiazole Core: A
Restorative Target in the Discovery of Potent Anti-cancer Agents |
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Yashab Fatima, Mahima S. Dayal, Tanvi S.
Lal, Imran Ahmad*
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ABSTRACT |
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In the past few decades, cancer has been
one of the crucial health issues and protruding reason of deaths to
humans. An appreciable advancement has been made in anti-cancer
drugs development and various new anticancer agents that have
natural as well as synthetic origin have been generated so far. Out
of different heterocyclic compounds, thiazole which is 5-membered
unique heterocyclic ring containing sulfur as well as nitrogen atoms
has an eminent function in several medicinally significant organic
compounds. Thiazole moiety has displayed several therapeutic actions
which also include anticancer activities and has been an elementary
part of clinically applied anticancer pharmaceutical drugs. Lately,
majority of the compounds extracted from natural sources that
contain thiazole component manifest significant cytotoxicities and
showcase antitumor capabilities as well. In this background, variety
of structural modifications has been made in the original structure,
which includes the inclusion of variety of substituents or the
incorporation with several other carbo- and also heterocycles, to
elevate the antitumoral efficacy. Moreover, these thiazole compounds
are less toxic and have been clinically proven to be highly
effective and have excellent potency for anticancer activity. This
review showcases the present phenomenal research on thiazoles and
illuminates their biological significance in the discovery of
anticancer drugs. The findings of this review article may help the
researchers in the cogent design of anti-cancer drug molecules that
are way more potent and bio-target specific in action. |
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Key words: Heterocyclic compounds,
Thiazole, Drug discovery, Cancerous cells, Anticancer agent
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KROS Publications |
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